Daijiworld Media Network - Texas

Texas, Mar 27: Bioengineers at Rice University have developed a new platform that could significantly improve the study of Metastasis, one of the deadliest aspects of cancer.

The system, named Advanced Tumor Landscape Analysis System (ATLAS), enables researchers to generate large quantities of cancer cell clusters that closely mimic how cancer behaves as it spreads through the bloodstream.

Developed in the lab of Michael King, the platform uses superhydrophobic surfaces—materials that repel water—to encourage cancer cells to group together into three-dimensional clusters. These clusters better represent the conditions cancer cells encounter during metastasis.

Researchers said the lack of reliable lab methods to replicate this complex process has long been a challenge in cancer research. ATLAS addresses this gap by offering a faster, more cost-effective and scalable solution using 3D-printed microwell arrays.

The team tested the system using prostate cancer cells and found that cancer cells travelling in clusters are more likely to survive, particularly when accompanied by support cells known as cancer-associated fibroblasts (CAFs). These cells help protect cancer cells from stress and aid their growth during circulation.

Lead researcher Alexandria Carter said the findings not only introduce a new research tool but also provide fresh biological insights. Scientists believe that targeting these support cells could open new pathways for preventing cancer spread in the future.

The innovation is also being prepared for commercial use through a startup initiative, signalling its potential for wider adoption in laboratories worldwide.

Experts noted that tools like ATLAS could accelerate cancer research by making experiments more realistic, efficient and accessible.