Diabetes drug could treat heart disease: Study

New York, Dec 21 (IANS): Researchers have discovered that metformin -- a drug commonly used to treat Type-2 diabetes -- might also be used to treat a specific form of heart failure known as preserved ejection fraction (HFpEF), finds a new study.

In a mice study, published in the journal of General Physiology, researchers showed that metformin relaxes a key heart muscle protein called titin, allowing the heart to properly fill with blood before pumping it around the body. This improves the animals' capacity for exercise.

"We therefore conclude that metformin is a potential therapy for patients with HFpEF," said Henk Granzier, Professor at the University of Arizona in the US.


"Because the drug is already approved and well tolerated in humans, using it to target titin stiffness presents a unique opportunity for immediate translation to the clinic," said Granzier.

HFpEF is more common in women and other risk factors include hypertension, old age, and obesity.

Unlike other forms of heart failure, however, there are currently no drugs available to treat HFpEF, according to the researchers.

Top Stories

Leave a Comment

Title : Diabetes drug could treat heart disease: Study


You have 2000 characters left.


Please write your correct name and email address. Kindly do not post any personal, abusive, defamatory, infringing, obscene, indecent, discriminatory or unlawful or similar comments. will not be responsible for any defamatory message posted under this article.

Please note that sending false messages to insult, defame, intimidate, mislead or deceive people or to intentionally cause public disorder is punishable under law. It is obligatory on Daijiworld to provide the IP address and other details of senders of such comments, to the authority concerned upon request.

Hence, sending offensive comments using daijiworld will be purely at your own risk, and in no way will be held responsible.

Security Validation

Enter the characters in the image