How genes decide recovery from alcoholism


Washington, Nov 5 (IANS): US researchers have identified genetic markers that may help in identifying individuals who could benefit from the alcoholism treatment drug Acamprosate.

Patients carrying these genetic variants have longer periods of abstinence during the first three months of Acamprosate treatment, showed the study.

When other environmental and physiological factors were considered, patients with the common allele (each of two or more alternative forms of a gene that arise by mutation and are found at the same place on a chromosome) located in the GRIN2B gene, stayed sober more days than those with a variant allele, found researchers.

Acamprosate is a commonly prescribed drug used to aid patients in recovery from alcoholism.

"This association finding is a first step towards development of a pharmacogenetic test allowing physicians to choose appropriate treatment for specific subgroups of alcohol-dependent patients," said Victor Karpyak, lead author and psychiatrist at the Mayo Clinic, Minnesota in the US.

They studied the link between variation in candidate genes and the length of sobriety in alcohol-dependent patients treated with Acamprosate in community-based programmes.

This finding was replicated in a sample of alcohol-dependent patients treated with Acamprosate in a study conducted by collaborators from Germany.

"We believe that individualized treatment selection will eliminate the need for trial-and-error approaches and improve treatment efficacy in patients with alcohol use disorders," Victor Karpyak added.

More studies are needed to determine potential importance of identified genetic variants in the longer-term effects of Acamprosate, as well as the molecular and physiological mechanisms behind the drug's action, concluded the researchers.

The findings appeared in the journal Translational Psychiatry.


Leave a Comment

Title : How genes decide recovery from alcoholism


 
 
 
 

 
You have 2000 characters left.

Disclaimer:

Please write your correct name and email address. Kindly do not post any personal, abusive, defamatory, infringing, obscene, indecent, discriminatory or unlawful or similar comments. Daijiworld.com will not be responsible for any defamatory message posted under this article.

Please note that sending false messages to insult, defame, intimidate, mislead or deceive people or to intentionally cause public disorder is punishable under law. It is obligatory on Daijiworld to provide the IP address and other details of senders of such comments, to the authority concerned upon request.

Hence, sending offensive comments using daijiworld will be purely at your own risk, and in no way will Daijiworld.com be held responsible.


Security Validation

Enter the characters in the image