Health

Hormone that protects women from liver cancer


London, Apr 5 (IANS): Researchers have discovered that a hormone -- present at higher levels in women -- can keep them away from liver cancer, suggesting the disease is more common in men.

The study showed that a potential contributor to this gender disparity is adiponectin, a hormone secreted by fat cells that helps control the body's metabolism.

The hormone activates two proteins inside liver cells, known as p38 and AMPK, that block cell proliferation and impair tumour growth, said the study, published in the Journal of Experimental Medicine.

"Circulating adiponectin levels have been reported to be higher in women than in men," said Guadalupe Sabio at the Spanish National Center for Cardiovascular Research (CNIC) in Spain.

Similar to humans, male mice are more also prone to hepatocellular carcinoma (HCC) -- the most common form of liver cancer -- than females, as the increased levels of adiponectin in female mice protect them from HCC, the study said.

Inhibiting testosterone production in male rodents increased their adiponectin levels and reduced tumour growth.

Importantly, the study suggested that adiponectin and metformin -- a common antidiabetic drug -- could be used as novel treatments for liver cancer.

Sabio said that adiponectin's role in HCC is controversial and needed further investigation.

Liver cancer is the fourth leading cause of cancer-related deaths worldwide.

Top Stories

Leave a Comment

Title : Hormone that protects women from liver cancer


 
 
 
 

 
You have 2000 characters left.

Disclaimer:

Please write your correct name and email address. Kindly do not post any personal, abusive, defamatory, infringing, obscene, indecent, discriminatory or unlawful or similar comments. Daijiworld.com will not be responsible for any defamatory message posted under this article.

Please note that sending false messages to insult, defame, intimidate, mislead or deceive people or to intentionally cause public disorder is punishable under law. It is obligatory on Daijiworld to provide the IP address and other details of senders of such comments, to the authority concerned upon request.

Hence, sending offensive comments using daijiworld will be purely at your own risk, and in no way will Daijiworld.com be held responsible.


Security Validation

Enter the characters in the image