Way to restore body's insulin producing ability

New York, Aug 1 (IANS): There is good news for patients suffering from type-one diabetes as they may soon be able to do away with their daily insulin dose to manage their blood-sugar levels.

Researchers have found that a peptide called caerulein can convert existing cells in the pancreas into those cells destroyed in type-one diabetes-insulin-producing beta cells.

"We have found a promising technique for type-one diabetics to restore the body's ability to produce insulin," said Fred Levine, a professor at Sanford-Burnham Medical Research Institute in the US.

"By introducing caerulein to the pancreas, we were able to generate new beta cells - the cells that produce insulin," Levine added.

The study first examined how mice in which almost all beta cells were destroyed - similar to humans with type-one diabetes - responded to injections of caerulein.

In those mice, but not in normal mice, they found that caerulein caused existing alpha cells in the pancreas to differentiate into insulin-producing beta cells.

The research team then examined human pancreatic tissue from type-one diabetics, finding strong evidence that the same process induced by caerulein also occurred in the pancreases of those individuals.

Caerulein is a peptide originally discovered in the skin of Australian Blue Mountains tree frogs.

It stimulates gastric, biliary, and pancreatic secretions, and has been used in humans as a diagnostic tool in pancreatic diseases.

An estimated over 300 million people worldwide are living with type-one diabetes.

The study appeared in the journal Cell Death and Disease.


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