Media Release
Mangaluru, Jan 19: The doctors at KMC Hospital, Dr B R Ambedkar Circle, Mangaluru have managed to perform a rare case of big kidney surgical removal on a 52-year-old female, Anuradha Paul (name changed) who was presented with a hugely enlarged abdomen due to both kidneys enlargement which is common in rare disease of autosomal dominant polycystic kidney disease (ADPKD).
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease that can lead to significant disability when complications develop. In ADPKD, fluid-filled cysts develop most of the time in both the kidneys, these cysts become bigger. It can get infected or can cause bleeding within the cysts. Also, ADPKD can progress to renal failure. The disease can significantly impact the quality of life.
After careful evaluation and planning, keeping her age in mind, a decision was made to remove her kidneys in a staged manner, one kidney at a time starting with the left kidney. The open surgical method was opted for as this is preferred considering the size. The patient underwent surgery uneventfully with excellent coordination between the teams of Urology led by Dr Sanman Gowda and the team, Dr Sushanth Kumar from Nephrology and Dr Madhusudhan Upadya, and a team from the Anaesthesiology department of KMC Hospital. The patient has resumed daily life.
Speaking after performing the surgery, Dr Sanman Gowda, consultant urologist, KMC Hospital, said, “Features of ADPKD often develop between the ages of 30 and 40 years and can eventually lead to kidney failure. In the past, this type was called adult polycystic kidney disease, but children can also develop the disorder. Only one parent needs to have the disease for it to pass to the children. If one parent has ADPKD, each child has a 50% chance of getting the disease. Both females and males can develop this disease. Although called a disease of the kidneys, it can affect the lungs and liver also.”
Dr Sushanth Kumar, consultant nephrologist, KMC Hospital said, “Mutations in either the PKD1 (16p13) or PKD2 (4q21) gene can cause autosomal dominant polycystic kidney disease; PKD1 gene mutations cause ADPKD type 1, and PKD2 gene mutations cause ADPKD type 2. These genes provide instructions for making proteins whose functions are to transmit chemical signals from outside the cell to the cell's nucleus. The two proteins work together to promote normal kidney development, organization, and function. Mutations in the PKD1 or PKD2 gene lead to the formation of thousands of cysts, which disrupt the normal functions of the kidneys and other organs.”
Commenting on the success of the treatment, Saghir Siddiqui, regional chief operating officer, KMC Hospital said, "KMC Hospital, Mangalore is one of the best hospitals in Mangalore which provide access to all the healthcare facilities in the neighborhood region from Kasargod in Kerala up to Karwar in Uttara Kannada district. However, this case was rare and the key findings can be crucial for many patients, and will help save many lives in the future. In this regard, I congratulate the team of Urologists, Nephrologists, and Anaesthesiology department and the entire team for the intricate diagnosis and treatments provided thus giving a better quality of life for the patient.”
About Manipal Hospitals:
As a pioneer in healthcare, Manipal Hospitals is among the top healthcare providers in India serving over 5 million patients annually. Its focus is to develop an affordable, high-quality healthcare framework through its multispecialty and tertiary care delivery spectrum and further extend it to out-of-hospital care. With the completion of the acquisition of AMRI Hospitals, the integrated network will have a pan-India footprint of 33 hospitals across 17 cities with 9,500 beds, a talented pool of over 5,000 doctors, and an employee strength of over 20,000.
Manipal Hospitals provides comprehensive curative and preventive care for a multitude of patients from around the globe. Manipal Hospitals is NABH, and AAHRPP accredited and most of the hospitals in its network are NABL, ER, and Blood Bank accredited and recognized for Nursing Excellence. Manipal Hospitals has also been recognized as the most respected and patient-recommended hospital in India through various consumer surveys.