Health

Chimp 'mini-brains' help decode how humans got big brains


New York, Feb 11 (IANS): US researchers, including one of an Indian-origin, have created mini brains of chimpanzee - our closest living relative - in laboratory that would help understand the development and organisation of huge brains in modern humans.

At some point during human evolution, a handful of genetic changes triggered a dramatic threefold expansion of the brain's neocortex, the wrinkly outermost layer of brain tissue responsible for everything from language to self-awareness to abstract thought.

Identifying what drove this evolutionary shift is fundamental to understanding what makes us human, the researchers said.

"By birth, the human cortex is already twice as large as in the chimpanzee, so we need to go back much earlier into embryonic development to understand the events that drive this incredible growth," said Arnold Kriegstein, Professor at University of California-San Francisco (UCSF).

In the study, published in the journal Cell, the team created chimpanzee brain "organoids" - small clusters of brain cells grown from stem cells in a laboratory dish.

They generated 56 organoids from stem cells derived from the skin of eight chimpanzees and 10 humans.

Researchers, led by Aparna Bhaduri, a postdoctoral researcher at UCSF, deconstructed human and chimpanzee organoids at different stages of development.

By looking for differences in gene activity between human organoids and chimp organoids (as well as reference tissue from another primate, the rhesus macaque monkey) Bhaduri identified several hundred genetic changes unique to the human lineage that could help explain the evolutionary origins of the distinctly human brain.

The team found that neural precursor cells, called outer radial glia (oRG) showed heightened activity of a key growth signaling network known as the mTOR pathway in human organoids.

"It was exciting to discover a molecular pathway in these cells that appears to have been specifically targeted during evolution and may help explain their specialised role in generating the advanced human cortex," Bhaduri said.

Problems with mTOR signalling have also been linked to autism and other uniquely human neurodevelopmental disorders, suggesting new questions about whether pathways involved in the relatively recent evolution of our unusually large brains play some special role in these disorders, she explained.

--IANS

rt/rs/ab


Leave a Comment

Title : Chimp 'mini-brains' help decode how humans got big brains


 
 
 
 

 
You have 2000 characters left.

Disclaimer:

Please write your correct name and email address. Kindly do not post any personal, abusive, defamatory, infringing, obscene, indecent, discriminatory or unlawful or similar comments. Daijiworld.com will not be responsible for any defamatory message posted under this article.

Please note that sending false messages to insult, defame, intimidate, mislead or deceive people or to intentionally cause public disorder is punishable under law. It is obligatory on Daijiworld to provide the IP address and other details of senders of such comments, to the authority concerned upon request.

Hence, sending offensive comments using daijiworld will be purely at your own risk, and in no way will Daijiworld.com be held responsible.


Security Validation

Enter the characters in the image